DESIGN, SYNTHESIS, AND INVESTIGATION OF NOVEL NITRIC OXIDE (NO)-RELEASING AROMATIC ALDEHYDES AS DRUG CANDIDATES FOR THE TREATMENT OF SICKLE CELL DISEASE

Sickle cell disease (SCD) is caused by a single-point mutation, and the ensuing deoxygenation-induced polymerization of sickle hemoglobin (HbS), and reduction in bioavailability of vascular nitric oxide (NO), contribute to the pathogenesis of the disease.In a proof-of-concept study, we successfully incorporated nitrate ester groups onto two previou

The viability and competitiveness of Staphylococcus xylosus in meat mostly depend on the ability to adapt itself to rapid oxygen and nutrients depletion during meat fermentation.The utilization of nitrite instead of oxygen becomes a successful strategy for this strain to improve its performance in anaerobiosis; however, metabolic pathways of this s

Dynamic spectrum access using cognitive radio has many application areas like smart-grid, Internet of Things, and various other device-to-device communication paradigms.In Lipstick dynamic spectrum access, a user picks a channel out of N channels to transmit during each time-slot.Thus, the user gets an arbitrary reward from a limited set of reward